Articles on Collaborative Health Research (2009 - 2023)

* denotes a trainee

Rheumatology

• Eder L, Croxford R, Drucker A, Mendel A, Kuriya B, Touma Z, Johnson S, Cook R, Bernatsky S, Haroon N, Widdifield J. Understanding COVID-19 risk in patients with immune mediated inflammatory diseases: A population-based analysis of COVID-19 testing. Arthritis Care and Research , 2023, 75 (2), 317-325. (Also appears in the American College of Rheumatology COVID-19 Collection)
• Kwok TSH, Sutton M, Cook RJ, Pereira D, Chandran V, Gladman DD. Musculoskeletal surgery in psoriatic arthritis: prevalence and risk factors. Journal of Rheumatology , 2023, 50 (4), 497-503.
• Perera S, Cook RJ, Lee K-A, Katz P, Touma Z. Intraindividual change in cognitive function among adults with systemic lupus erythrematosus: A Markov analysis over 7 years. ACR Open Rheumatology , 2023, 5 (3), 124-131.
• Rida M-A, Lee K-A, Chandran V, Cook RJ, Gladman DD. Persistence of biologics in the treatment of psoriatic arthritis (PsA): Data from a large hospital based longitudinal cohort. Arthritis Care & Research , published online on March 13, 2023.


• Colaco K, Lee K-A, Akhtari S, Winer R, Welsh P, Sattar N, McInnes I, Chandran V, Harvey P, Cook RJ, Gladman D, Piguet V, Eder L. Association of cardiac biomarkers with cardiovascular outcomes in patients with psoriatic arthritis and psoriasis: a longitudinal cohort study. Arthritis & Rheumatology , 2022, 74 (7), 1184-1192.
• Eder L, Croxford R, Drucker AM, Mendel A, Kuriya B, Touma Z, Johnson SR, Cook R, Bernatsky S, Haroon N, Widdifield J. COVID-19 hospitalizations, intensive care unit stays, ventilation and death among patients with immune mediated inflammatory diseases compared to controls. Journal of Rheumatology , 2022, 49 (5), 523-530.
• Kwok TSH, Sutton M, Pereira D, Cook RJ, Chandran V, Haroon N, Inman RD, Gladman DD. Isolated axial disease in psoriatic arthritis and ankylosing spondylitis with psoriasis. Annals of the Rheumatic Diseases , 2022, 81 (12), 1678-1684.
• Sarabia S, Farrer C, Yeung J, Jerome D, Cook RJ and Eder L. Comparative efficacy of different triage methods for psoriatic arthritis: prospective study in a rapid access clinic. Arthritis Care and Research , 2022, 74 (8), 1254-1262.
• Wong A, Ye JY, Cook RJ, Gladman DD, Chandran V. Depression and anxiety reduce the probability of achieving a state of sustained minimal disease activity in patients with psoriatic arthritis. Arthritis Care and Research , 2022, 74 (9), 1430-1434.


• Colaco K, Lee K-A, Akhtari S, Winer R, Welsh P, Sattar N, McInnes IB, Chandran V, Harvey P, Cook RJ, Gladman DD, Piguet V, Eder L. Targeted metabolomic profiling and prediction of cardiovascular events: a prospective study of patients with psoriatic arthritis and psoriasis. Annals of the Rheumatic Diseases , 2021, 80 (11), 1429-1435.
• Damian AC, Colaco K, Rohekar S, Chandran V, Gladman DD, Cook RJ, Eder L. The incidence and risk factors for venous thromboembolic events in patients with psoriasis and psoriatic arthritis. Seminars in Arthritis and Rheumatism , 2021, 51 (3), 547-552.
• Feld J, Ye JY, Chandran V, Inman RD, Haroon N, Cook RJ, Gladman DD. Axial disease in psoriatic arthritis: The presence and progression of unilateral grade 2 sacroiliitis in a psoriatic arthritis cohort. Seminars in Arthritis and Rheumatism , 2021, 51 (2), 464-468.
• Gladman DD, Ye JY, Chandran V, Lee K-A and Cook RJ. Oligoarticular versus polyarticular psoriatic arthritis: a longitudinal study showing similar characteristics. Journal of Rheumatology , 2021, 48 (12), 1824-1829.
• Koppikar S, Colaco K, Harvey P, Akhtari S, Chandran V, Gladman DD, Cook RJ, Eder L. Incidence of and risk factors for heart failure in patients with psoriatic disease - a cohort study. Arthritis Care and Research , 2022, 74 (8), 1244-1253.
• Polachek A, Muntyanu A, Lee K-A,Ye JY, Chandran V, Cook RJ, Gladman DD. Malignancy in psoriatic disease: results from prospective longitudinal cohorts. Seminars in Arthritis and Rheumatism , 2021, 51 (1), 144-149.
• Sarabia S, Farrer C, Yeung J, Jerome D, Lee K-A, Cook RJ, Eder L. The pattern of musculoskeletal complaints in patients with suspected psoriatic arthritis and their correlation with physical examination and ultrasound. Journal of Rheumatology , 2021, 48 (2), 214-221.


• Abji F, Lee K-A, Pollock RA, Machhar R, Cook RJ, Chandran V, Gladman DD. Declining levels of serum chemokine (C‐X motif) ligand 10 over time are associated with new onset of psoriatic arthritis in patients with psoriasis: a new biomarker? British Journal of Dermatology , 2020, 183 (5), 920-927.
• Abji F, Ye JY, Cook RJ, Oikonomopoulou K, Chandran V. The association between synovial fluid serine proteinase activity and response to intra-articular corticosteroid injection in psoriatic arthritis. Clinical Rheumatology , 2020, 39 , 2355-2361.
• Alharbi S, Ye JY, Lee K-A, Chandran V, Cook RJ, Gladman DD. Remission in psoriatic arthritis: definition and predictors. Seminars in Arthritis and Rheumatism , 2020, 50 (6), 1494-1499.
• Elalouf O, Muntyanu A, Polachek A, Pereira D, Ye JY, Lee K-A, Chandran V, Cook RJ, Gladman DD. Mortality in psoriatic arthritis: Risk, causes of death, predictors for death. Seminars in Arthritis and Rheumatism , 2020, 50 (4), 571-575.
• Feld J, Ye JY, Chandran V, Inman RD, Haroon N, Cook RJ, Gladman DD. Is axial psoriatic arthritis distinct from ankylosing spondylitis with and without concomittant psoriasis? Rheumatology , 2020, 59 , 1340-1346.
• Pakchotanon R, Ye JY, Cook RJ, Chandran V, Gladman DD. Liver abnormalities in patients with psoriatic arthritis. Journal of Rheumatology , 2020, 47 (6), 847-853.


• Chandran V, Abji F, Perruccio AV, Gandhi R, Li S, Cook RJ and Gladman DD. Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis. Annals of the Rheumatic Diseases , 2019, 78 (6), 796-801.
• Eder L, Widdifield J, Rosen CF, Cook R, Lee K-A, Alhusayen R, Paterson MJ, Cheng SY, Jabbari S, Campbell I, Bernatsky S, Gladman DD, Tu K. Trends in the prevalence and incidence of psoriasis and psoriatic arthritis in Ontario, Canada: A population-based study. Arthritis Care & Research , 2019, 71 (8), 1084-1091.
• Sobchak C, Akhtari S, Harvey P, Gladman D, Chandran V, Cook R, Eder L. Value of carotid ultrasound in cardiovascular risk stratification in patients with psoriatic disease. Arthritis and Rheumatology , 2019, 71 (10), 1651-1659.
• Tom S, Zhong Y*, Cook R, Aydin SZ, Kaeley G, Eder L. Development of a preliminary ultrasonographic enthesitis score in psoriatic arthritis: GRAPPA ultrasound working group. The Journal of Rheumatology , 2019, 46 (4), 384-390.
• Wakhlu A, Chandran V, Phumethum V, Shen H, Cook RJ, Gladman DD. Comparison between INSPIRE and domjan method for measuring lumbar lateral flexion in patients of psoriatic arthritis (PsA) and correlation with radiographic damage. Clinical Rheumatology , 2019, 38 (4), 1063-1066.
• Zhou W, Chandran V, Cook R, Gladman DD, Eder L. The association between occupational-related mechanical stress and radiographic damage in psoriatic arthritis. Seminars in Arthritis and Rheumatism , 2019, 48 (4), 638-643.


• Eder L, Joshi AA, Dey AK, Cook R, Siegel EL, Gladman DD, Mehta NN. Association of tumor necrosis factor inhibitor treatment with reduced indices of subclinical atherosclerosis in patients with psoriatic disease. Arthritis and Rheumatology , 2018, 70 (3), 408-416.
• Polachek A, Cook RJ, Chandran V, Abji F, Gladman DD, Eder L. The association between HLA genetic susceptibility markers and sonographic enthesitis in psoriatic arthritis. Arthritis and Rheumatology , 2018, 70 (5), 756-762.


• Eder L, Chandran V, Cook RJ, Gladman DD. The risk of developing diabetes mellitus in patients with psoriatic arthritis: a cohort study. The Journal of Rheumatology , 2017, 44 (3), 286-291.
• Eder L, Polachek A, Rosen CF, Chandran V, Cook R, Gladman DD. The development of PsA in patients with psoriasis is preceded by a period of non-specific musculoskeletal symptoms: a prospective cohort study. Arthritis & Rheumatology , 2017, 69 (3), 622-629.
• Ibrahim A, Gladman DD, Thavaneswaran A, Eder L, Helliwell P, Cook RJ, Chandran V. Sensitivity and specificity of radiographic scoring instruments for detecting change in axial psoriatic arthritis. Arthritis Care and Research , 2017, 69 (11), 1700-1705.
• Medina-Rosas J, Su J, Cook RJ, Sabapathy A, Touma Z. Comparison of spot urine protein to creatinine ratio to 24-hour proteinuria to identify important change over time in proteinuria in lupus. JCR: Journal of Clinical Rheumatology , 2017, 23 (6), 301-307.
• Polachek A, Cook R, Chandran V, Gladman DD, Eder L. The association between sonographic enthesitis and radiographic damage in psoriatic arthritis. Arthritis Research & Therapy , 2017, 19 (1), 189. DOI: 10.1186/s13075-017-1399-5


• Eder L, Abji F, Rosen CF, Chandran V, Cook RJ, Gladman D. The association of HLA-class I genes and the extent of atherosclerotic plaques in patients with psoriatic disease. Journal of Rheumatology , 2016, 43 (10), 1844-1851.
• Eder L, Haddad A, Rosen CF, Lee K-A, Chandran V, Cook RJ, Gladman DD. The incidence and risk factors for psoriatic arthritis in patients with psoriasis - a prospective cohort study. Arthritis & Rheumatology , 2016, 68 (4), 915-923.
• Eder L, Wu Y*, Chandran V, Cook RJ, Gladman DD. Incidence and predictors for cardiovascular events in patients with psoriatic arthritis. Annals of Rheumatic Disease , 2016, 75 (9), 1680-1686.
• Haddad A, Li S, Thavaneswaran A, Cook RJ, Chandran V and Gladman DD. The incidence and predictors of infection in psoriasis and psoriatic arthritis: results from longitudinal observational cohorts. The Journal of Rheumatology , 2016, 43 (2), 362-366.
• Touma Z, Thavaneswaran A, Chandran V, Pellett F, Cook RJ, Gladman DD. Clinical and demographic characteristics of erosion-free and erosion-present status in psoriatic arthritis in a prospective cohort study. Journal of Rheumatology , 2016, 43 (6), 1057-1062.


• Eder L, Thavaneswaran A, Chandran V, Cook RJ, Gladman D. Factors explaining the discrepancy between physician and patient global assessment of joint and skin disease activity in psoriatic arthritis patients. Arthritis Care & Research , 2015, 67 (2), 264-272.
• Eder L, Thavaneswaran A, Chandran V, Cook R, Gladman DD. Increased burden of inflammation over time is associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis. Annals of the Rheumatic Diseases , 2015, 74 (10), 1830-1835.
• Eder L, Thavaneswaran A, Chandran V, Cook RJ, Gladman DD. Obesity is associated with a lower probability of achieving sustained minimal disease activity state among patients with psoriatic arthritis. Annals of the Rheumatic Diseases , 2015, 74 (5), 813-817.
• Haddad A, Thavaneswaran A, Arruza IR, Pellett F, Chandran V, Cook RJ, Gladman DD. Minimal disease activity and anti-TNF therapy in psoriatic arthritis. Arthritis Care & Research , 2015, 67 (6), 842-847.


• Biagioni BJ, Gladman DD, Cook RJ, Eder L, Wakhlu A, Shen H*, Chandran V. Reliability of radiographic scoring methods in axial psoriatic arthritis. Arthritis Care & Research , 2014, 66 (9), 1417-1422.


• Chandran V, Shen H*, Pollock RA, Pellett RA, Carty A, Cook RJ, Gladman DD. Soluble biomarkers associated with response to treatment with tumour necrosis factor inhibitors in psoriatic arthritis. Journal of Rheumatology , 2013, 40 (6), 866-871.


• Eder L, Shanmugarajah S, Thavaneswaran A, Chandran V, Rosen CF, Cook RJ, Gladman DD. The association between smoking and the development of psoriatic arthritis among psoriasis patients. Annals of the Rheumatic Diseases , 2012, 71 (2), 219-224.


• Bookman AAM, Shen H*, Cook RJ, Bailey D, McComb RJ, Rutka JA, Slomovic AR, Caffery B. Whole stimulated salivary flow: Correlation with the pathology of inflammation and damage in minor salivary gland biopsy specimens from patients with primary Sjogren's syndrome but not patients with sicca. Arthritis & Rheumatism , 2011, 63 (7), 2014-2020.
• Eder L, Chandran V, Shen H*, Cook RJ, Shanmugarajah S, Rosen CF, Gladman DD. Incidence of arthritis in a prospective cohort of psoriasis patients. Arthritis Care & Research , 2011, 63 (4), 619-622.
• Eder L, Law T, Chandran V, Shanmugarajah S, Shen H*, Rosen CF, Cook RJ, Gladman DD. Association between environmental factors and onset of psoriatic arthritis in patients with psoriasis. Arthritis Care & Research , 2011, 63 (8), 1091-1097.
• Gladman DD, Rahman P, Cook RJ, Shen H*, Zummer M, Thomson G, Nair B, Rohekar S, Ayearst R, Inman RD, Maksymowych WP. The SpondyloArthritis Research Consortium of Canada Registry for Spondyloarthritis. The Journal of Rheumatology , 2011, 38 (7), 1343-1348.
• Gladman DD, Thavanswaran A, Chandran V and Cook RJ. Do patients with psoriatic arthritis who present early fare better than those presenting later in the disease? Annals of the Rheumatic Diseases , 2011, 70 (12), 2152-2154.
• Husted JA, Thavaneswaran A, Chandran V, Eder L, Rosen CF, Cook RJ, Gladman DD. Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis. Arthritis Care & Research , 2011, 63 (12), 1729-1735.
• Lui NL, Carty A, Haroon N, Shen H*, Cook RJ, Inman RD. Clinical correlates of urolithiasis in ankylosing Spondylitis. The Journal of Rheumatology , 2011, 38 (9), 1953-1956.
• Lui NL, Haroon N, Carty A, Shen H*, Cook RJ, Shanmugarajah S, Gladman DD, Inman RD. Effect of pregnancy on ankylosing Spondylitis: A case-control study. The Journal of Rheumatology , 2011, 38 (11), 2442-2444.
• Touma Z, Eder L, Zisman D, Feld J, Chandran V, Rosen CF, Shen H*, Cook RJ, Gladman DD. Seasonal variation in vitamin D levels in psoriatic arthritis patients from different latitudes and its association with clinical outcomes. Arthritis Care and Research , 2011, 63 (10), 1440-1447.


• Chandran V, Cook RJ, Edwin J, Shen H*, Pellett FJ, Shanmugarajah S, Rosen CF, Gladman DD. Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis. Rheumatology , 2010, 49 (7), 1399-1405.
• Chandran V, Tolusso DC*, Cook RJ and Gladman DD. Risk factors for axial inflammatory arthritis in patients with psoriatic arthritis. The Journal of Rheumatology , 2010, 37 (4), 809-815.
• Coates LC, Cook RJ, Lee K-A, Chandran V, Gladman DD. Frequency, predictors and prognosis of sustained minimal disease activity in an observational psoriatic arthritis cohort. Arthritis Care & Research , 2010, 62 (7), 970-976.
• Eder L, Chandran V, Schentag CT, Shen H*, Cook RJ, Gladman DD. Time and predictors of response to tumour necrosis factor - $\alpha$ blockers in psoriatic arthritis: An analysis of a longitudinal observational cohort. Rheumatology , 2010, 49 (7), 1361-1366.
• Eder L, Chandran V, Shen H*, Cook RJ, Gladman DD. Is ASDAS better than BASDAI as a measure of disease activity in axial psoriatic arthritis? Annals of Rheumatic Diseases , 2010, 69 (12), 2160-2164.
• Eder L, Chandran V, Ueng J, Bhella S, Lee K-A, Rahman P, Pope A, Cook RJ, Gladman DD. Predictors of response to intra-articular steroid injection in psoriatic arthritis. Rheumatology , 2010, 49 (7), 1367-1373.


• Chandran V, Gottlieb A, Cook RJ, Duffin KC, Garg A, Helliwell P, Kavanaugh A, Krueger GG, Langley RG, Lynde C, McHugh N, Mease P, Olivieri I, Rahman P, Rosen CF, Salvarani C, Thaci D, Toloza SMA, Wong MYW, Zhou QM, Gladman DD. International multicenter psoriasis and psoriatic arthritis reliability trial for the assessment of skin, joints, nails, and dactylitis. Arthritis & Rheumatism , 2009, 61 (9), 1235-1242.

Hematology and Transfusion Research

• Kaur MN, Arnold DM, Heddle NM, Cook RJ, Hsia C, Blostein M, Jamula E, Sholzberg M, Lin Y, Kassis J, Larratt L, Tinmouth A, Carruthers J, Li N, Lui Y, Kelton JG, Xie F. Cost-effectiveness of eltrombopag versus intravenous immunoglobulin for the perioperative management of immune thrombocytopenia. Blood Advances , 2022, 6 (3), 785-792.


• Begin P, Callum J, Jamula E, Cook R, Heddle NM, Tinmouth A, Zeller MP, Beaudoin-Bussieres G, Amorim L, Bazin R, Loftsgard KC, Carl R, Chasse M, Cushing MM, Daneman N, Devine DV, Dumaresq D, Fergusson DA, Gabe C, Glesby MJ, Li N, Liu Y, McGeer A, Robitaille N, Sachais BS, Scales DC, Schwartz L, Shehata N, Turgeon AF, Wood H, Zarychanski R, Finzi A, the CONCOR-1 Study Group and Arnold DM. Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. Nature Medicine , 2021, 27 , 2012-2024.
• Begin P, Callum J, Heddle N, Cook R, Zeller MP, Tinmouth A, Fergusson D, Cushing MM, Glesby MJ, Chasse M, Devine DV, Robitaille N, Bazin R, Shehata N, Finzi A, McGeer A, Scales D, Schwartz L, Turgeon AF, Zarychanski R, Daneman N, Carl R, Amorim L, Gabe C, Ellis M Jamula E, Carruthers J, Duncan J, Lucier K, Armali C, Kron A, Modi D, Auclair M-C, Avram M, Arnold DM. Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): Study protocol for an international, multicenter, randomized, open-label trial. Trials , 2021, 22 , Article No: 323.
• Weiskopf RB and Cook RJ. The known and unknown unknowns in making transfusion decisions (Editorial). Anesthesiology , 2021, 134 , 359-362.


• Arnold DM, Heddle NM, Cook RJ, Hsia C, Blostein M, Jamula E, Sholzberg M, Lin Y, Kassis J, Larratt L, Tinmouth A, Amini S, Schipperus M, Lim W, Vishnu P, Warner M, Carruthers J, Li N, Lane S, Kelton JG. Perioperative oral eltrombopag versus intravenous immunoglobulin in patients with immune thrombocytopenia: a non-inferiority, multicentre, randomised trial. The Lancet Haematology , 2020, 7 (9), e640-e648.
• Warkentin TE, Cook RJ and Greinacher A. Limitations of the particle immunofiltration assay (PIFA) test for diagnosis of heparin-induced thrombocytopenia (HIT). American Journal of Hematology , 2020, 95 (9), E250-E254.


• Arnold DM, Jamula E, Heddle NM, Cook RJ, Hsia C, Sholzberg M, Lin Y, Kassis J, Blostein M, Larratt L, Amini S, Schipperus M, Carruthers J, Lane S, Li N, Kelton JG. Peri-Operative eltrombopag or immune globulin for patients with immune thrombocytopenia (the bridging ITP trial): methods and rationale. Thrombosis and Haemostasis , 2019, 119 (03), 500-507.
• Heddle NM, Cook RJ, Liu Y, Zeller M, Barty R, Acker JP, Eikelboom J, Arnold DM. The association between blood donor sex and age and transfusion recipient mortality: an exploratory analysis. Transfusion , 2019, 59 (2), 482-491.
• Ning S, Liu Y, Barty R, Cook R, Rochwerg B, Iorio A, Warkentin TE, Heddle NM, Arnold DM. The association between platelet transfusions and mortality in patients with critical illness. Transfusion , 2019, 59 (6), 1962-1970.


• Shih AWY, Liu A, Elsharawi R, Crowther MA, Cook RJ, Heddle NM. Systematic reviews of guidelines and studies for single versus multiple unit transfusion strategies. Transfusion , 2018, 58 (12), 2841-2860.
• Cook RJ, Weiskopf RB. Observing blood management programs through the retrospectroscope (Editorial). Anesthesiology , October 11, 2018. DOI:10.1097/ALN.0000000000002477


• Barty RL, Pai M, Liu Y, Donald AM, Cook RJ, Zeller M, Heddle NM. Group O RBCs: Where is universal donor blood being used? Vox Sanguinis , 2017, 112 (4), 336-342.
• Cook RJ, Heddle NM, Lee K-A, Arnold DM, Crowther MA, Devereaux PJ, Ellis M, Figueroa P, Kurz A, Roxby D, Sessler DI, Sharon Y, Sobieraj-Teague M, Warketin TE, Webert KE, Barty R, Liu Y, Eikelboom JW. Red blood cell storage and in-hospital mortality: a secondary analysis of the INFORM randomised controlled trial. The Lancet Hematology , 2017, 4 (11), e544-e552.
• Weiskopf RB and Cook RJ. Demonstrating therapeutic equivalence of a new and established pharmaceutical or intervention: a guide for the non-statistician. Transfusion , 2017, 57 (6), 1343-1346.
• Weiskopf RB and Cook RJ. Understanding non-inferiority trials and tests for the non-statistician: when to use them and how to interpret them. Transfusion , 2017, 57 (2), 240-243.


• Eikelboom JW, Cook RJ, Barty R, Liu Y, Arnold DM, Crowther MA, Devereux PJ, Ellis M, Figueroa P, Gallus A, Hirsh J, Kurz A, Roxby D, Sessler DI, Sharon Y, Sobieraj-Teague M, Warkentin TE, Webert KE, Heddle NM. Rationale and design of the informing fresh versus old red cell management (INFORM) trial: an international pragmatic randomized trial. Transfusion Medicine Reviews , 2016, 30 (1), 25-29.
• Heddle NM, Cook RJ, Arnold DM, Liu Y, Barty R, Crowther MA, Devereaux PJ, Hirsh J, Warkentin TE, Webert KE, Roxby D, Sobieraj-Teague M, Kurz Sessler DI, Figueroa P, Ellis M, Eikelboom JW. Effect of short-term vs. long-term blood storage on mortality after transfusion. New England Journal of Medicine , 2016, 375 (20), 1937-1945.
• Heddle NM, Arnold DM, Acker JP, Liu Y, Barty R, Eikelboom J, Webert KE, Hsia C, O'Brien SF, Cook RJ. Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study. The Lancet Haematology , 2016, 3 (5), e246-e254.
• Pai M, Cook R, Barty R, Eikelboom J, Lee K-A, Heddle N. Exposure to ABO non-identical blood associated with increased in-hospital mortality in patients with group A blood. Transfusion , 2016, 56 (3), 550-557.
• Solh Z, Athale U, Arnold DM, Cook RJ, Foley R, Heddle HM. Transfusion-related alloimmunization in children: epidemiology and effects of chemotherapy. Vox Sanguinis , 2016, 111 (3), 299-307.


• Heddle NM, Eikelboom J, Liu Y, Barty R, Cook RJ. Exploratory studies on the age of transfused blood and in-hospital mortality in patients with cardiovascular diagnoses. Transfusion , 2015, 55 (2), 364-372.
• Warkentin TE, Cook RJ, Sarode R, Sloane DA, Crowther MA. Warfarin-induced venous limb ischemia/gangrene complicating cancer: a novel and clinically distinct syndrome. Blood , 2015, 126 (4), 486-493.


• Mahan CE, Liu Y, Turpie AG, Vu JT, Heddle N, Cook RJ, Dairkee U, Spyropoulos AC. External validation of a risk assessment model for venous thromboembolism in the hospitalised acutely-ill medical patient (VTE-VALOURR). Thrombosis and Haemostasis , 2014, 112, 692-699.


• Cook RJ and Heddle N. Clinical trials evaluating pathogen-reduced platelet products: methodological issues and recommendations. Transfusion , 2013, 53 (8), 1843-1855.
• Mahabir VK, Ross C, Popovic S, Sur ML, Bourgeois J, Lim W, George JN, Wang G, Cook RJ, Toltl LJ, Nazi I, Kelton JG, Arnold DM. A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia. European Journal of Haematology , 2013, 90 (2), 121-126.
• Nazi I, Kelton JG, Larche M, Snider DP, Heddle NM, Crowther MA, Cook RJ, Tinmouth AT, Mangel J, Arnold DM. The effect of rituximab on vaccine responses in patients with immune thrombocytopenia. Blood , 2013, 122 (11), 1946-1953.


• Arnold DM, Heddle NM, Carruthers J, Cook DJ, Crowther MA, Meyer RM, Liu Y, Cook RJ, McLeod A, MacEachern JA, Mangel J, Anderson D, Vickars L, Tinmouth A, Schuh AC, Kelton JG. A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia. Blood , 2012, 119 (6), 1356-1362.
• Heddle NM, Cook RJ, Arnold DM, Crowther MA, Warkentin TE, Webert KE, Hirsh J, Barty RL, Liu Y, Lester C, Eikelboom JW. The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial. Transfusion , 2012, 52 (6), 1203-1212.
• Warkentin TE, Pai M and Cook RJ. Intraoperative anticoagulation and limb amputations in patients with immune heparin-induced thrombocytopenia who require vascular surgery. Journal of Thrombosis and Hemostasis , 2012, 10 (1), 148-150.


• Heddle NM and Cook RJ. Composite outcomes in clinical trials: what are they and when should they be used? Transfusion , 2011, 51 (1), 11-13.
• Warkentin TE and Cook RJ. Impact of laboratory testing for heparin-induced antibodies: using Bayes' rule to prevent overdiagnosis of heparin-induced thrombocytopenia. LaboratoriumsMedizin/Journal of Laboratory Medicine , 2011, 35 (1), 45-54.


• Cazenave J-P, Follea G, Bardiaux L, Boiron J-M, Lafeuillade B, Debost M, Lioure B, Harousseau J-L, Tabrizi R, Cahn J-Y, Michallet M, Ambruso D, Schots R, Tissot J-D, Sensebe L, Kondo T, McCullough J, Rebulla P, Escolar G, Mintz P, Heddle NM, Goodrich RP, Bruhwyler J, Le C, Cook RJ, Stouch B and for members of the The Mirasol Clinical Evaluation Study Group. A randomized controlled clinical trial evaluating the performance and safety of platelets treated with MIRASOL pathogen reduction technology. Transfusion , 2010, 50 (11), 2362-2375.
• Eikelboom JW, Cook RJ, Liu Y* and Heddle NM. Duration of red cell storage before transfusion and in-hospital mortality. American Heart Journal , 2010, 159 (5), 737-743.
• Warkentin TE, Cook RJ, Marder VJ and Greinacher A. Anti-PF4/heparin antibody formation post-orthopedic surgery thromboprophylaxis: the role of non-drug risk factors and evidence for a stoichiometry-based model of immunization. Journal of Thrombosis and Haemostasis , 2010, 8 (3), 504-512.


• Cook RJ and Heddle NM. Measuring and reporting the effect of an intervention: relative measures. Transfusion , 2009, 49 (1), 9-12.
• Cook RJ and Heddle NM. Measuring and reporting the effect of an intervention: absolute measures. Transfusion , 2009, 49 (10), 2022-2023.
• Hayward CPM, Pai M, Lui Y, Moffat KA, Seecharan J, Webert KE, Cook RJ, Heddle NM. Diagnostic utility of light transmission platelet aggregometry: results from a retrospective study in individuals referred for bleeding disorder assessments. Journal of Thrombosis and Haemostasis , 2009, 7 (4), 676-684.
• Heddle NM, Cook RJ, Tinmouth A, Kouroukis CT, Hervig T, Klapper E, Brandwein JM, Szczepiorkowski ZM, AuBuchon JP, Barty RL, Lee K-A, and for the STOP Study Investigators of the BEST Collaborative. A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) for patients with thrombocytopenia. Blood , 2009, 113 (7), 1564-1573.
• Warkentin TE, Sheppard JI, Moore JC, Cook RJ, Kelton JG. Studies of the immune response in heparin-induced thrombocytopenia. Blood , 2009, 113 (20), 4963-4969.

Cancer Research

• Al-Shamsi HO, Farsi AA, Anjum M, Shen H*, Zbuk K, Cook RJ, Linkins L-A, Major P. Thrombotic events in metastatic colorectal cancer patients treated with leucovorin, fluorouracil and irinotican (FOLFIRI) plus bevacizumab. Journal of Gastrointestinal Oncology , 2015, 6 (3), 274-279.


• Coleman RE, Lipton A, Costa L, Cook RJ, Lee K-A, Saad F, Brown JE, Terpos E, Major PP, Kohno N, Smith M, Body J-J. Possible survival benefits from Zoledronic acid treatment in patients with bone metastases from solid tumours and poor prognostic features - An exploratory analysis of placebo-controlled trials. Journal of Bone Oncology , 2013, 2 (2), 70-76.
• Lipton A, Cook R, Brown J, Body JJ, Smith M, Coleman R. Skeletal-related events and clinical outcomes in patients with bone metastases and normal levels of osteolysis: exploratory analyses. Clinical Oncology , 2013, 25 (4), 217-226.


• Berruti A, Cook RJ, Saad F, Buttigliero C, Lipton A, Tampellini M, Lee K-A, Coleman RE, Smith MR. Prognostic role of serum parathyroid hormone levels in advanced prostate cancer patients undergoing zoledronic acid administration. The Oncologist , 2012, 17 (5), 645-652.
• Brown JE, Cook RJ, Lipton A, Coleman RE. Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: a retrospective analysis in bisphosphonate-treated patients. Clinical Cancer Research , 2012, 18 (22), 6348-6355.


• Coleman RE, Cook RJ, Hirsh V, Major P, Lipton A. Zoledronic acid use in cancer patients - more than just supportive care? Cancer , 2011, 117 (1), 11-23.
• Coleman R, Costa L, Saad F, Cook RJ, Hadji P, Terpos E, Garnero P, Brown J, Body JJ, Smith M, Lee K-A, Major P, Dimopoulos M, Lipton A. Consensus on the utility of bone markers in the malignant bone disease setting. Critical Reviews in Oncology/Hematology , 2011, 80 (3), 411-432.
• Smith MR, Cook RJ, Lee K-A and Nelson JB. Disease and host characteristics as predictors of time to first bone metastasis and survival in men with progressive castration-resistant nonmetastatic prostate cancer. Cancer , 2011, 117 (10), 2077-2085.


• Brown JE, Cook RJ, Lipton A, Costa L, Coleman RE. Prognostic factors for skeletal complications from metastatic bone disease in breast cancer. Breast Cancer Research and Treatment , 2010, 123 (3), 767-779.
• Terpos E, Berenson J, Cook RJ, Lipton A, Coleman RE. Prognostic variables for survival and skeletal complications in patients with multiple myeloma osteolytic bone disease. Leukemia , 2010, 24 (5), 1043-1049.


• Major PP, Cook RJ, Lipton A, Smith MR, Terpos E Coleman RE. Natural history of malignant bone disease in breast cancer and the use of cumulative mean functions to measure skeletal morbidity. BMC Cancer , 2009, 9, 1-12.

Other Medical Research

• Gohari MR, Taylor M, MacKinnon MC, Panagiotoglou D, Kaplan GG, Galanis GG, Cook RJ, Patric DM, Ethelberg S and Majowicz SE. Patterns of enteric infections in a population-wide cohort study of sequelae, British Columbia, Canada. Epidemiology and Infection , 2023, 151 , E7. https://doi.org/10.1017/S0950268822001911


• Stolee P, Elliott J, Giguere AMC, Mallinson S, Rockwood K, Gould JS, Baker R, Boscart V, Burns C, Byrne K, Carson J, Cook RJ, Costa AP, Giosa J, Grindrod K, Hajizadeh M, Hanson HM, Hastings S, Heckman G, Holroyd-Leduc J, Isaranuwatchai W, Kuspinar A, Meyer S, McMurray J, Puchyr P, Puchyr P, Theou O, Witterman H. Transforming primary care for older Canadians living with frailty: mixed methods study protocol for a complex primary care intervention. BMJ Open , 2021, 11 (5), e042911.
• Gohari MR, Cook RJ, Dubin JA, Leatherdale ST. The impact of an alcohol policy change on developmental trajectories of youth alcohol use: examination of a natural experiment in Canada. Canadian Journal of Public Health , 2021, 112 , 210-218.


• Gohari MR, Cook RJ, Dubin JA, Leatherdale ST. Identifying patterns of alcohol use among secondary school students in Canada: a multilevel latent class analysis. Addictive Behaviors , 2020, 100 , 106120. DOI: 10.1016/j.addbeh.2019.106120
• Majowicz SE, Panagiotoglou D, Taylor M, Gohari MR, Kaplan GG, Chaurasia A, Leatherdale ST, Cook RJ, Patrick DM, Ethelberg S, Galani E. Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study. BMJ Open , 2020, 10 (8), e036560.


• Gohari MR, Dubin JA, Cook RJ, Leatherdale ST. Original quantitative research Identifying trajectories of alcohol use among a sample of secondary-school students in Ontario and Alberta: longitudinal evidence from the COMPASS study. Health Promotion and Chronic Disease Prevention in Canada: Research, Policy & Practice , 2019, 39 (8-9), 244-253.


• Yan Q, Ding Y, Liu Y, Sun T, Fritsche LG, Clemons T, Ratnapriya R, Klein ML, Cook RJ, Liu Y, Fan R, Wei L, Abecasis GR, Swaroop A, Chew EY, AREDS2 research group, Weeks DE, Chen W. Genome-wide analysis of disease progression in age-related macular degeneration. Human Molecular Genetics , 2018, 27 (5), 929-940.


• Ding Y, Liu Y, Yan Q, Fritsche LG, Cook RJ, Clemons T, Ratnapriya R, Klein ML, Abecasis GR, Swaroop A, Chew EY, Weeks DE, Chen W. Bivariate analysis of age-related macular degeneration progression using genetic risk scores. Genetics , 2017, 206 (1), 119-133.


• Wang H, Dasgupta A, Lee K-A, Cook RJ, Nair P. Changing pattern of sputum cell counts during successive exacerbations of chronic obstructive pulmonary disease. Journal of Chronic Obstructive Pulmonary Disease , 2015, 12 (6), 628-635.


• Garg AX, Devereaux PJ, Yusuf S, Cuerden MS, Parikh CR, Coca SG, Walsh M, Novick R, Cook RJ, Jain AR, Pan X, Noiseux N, Vik K, Stolf NA, Ritchie A, Favaloro RR, Parvathaneni S, Whitlock RP, Ou Y, Lawrence M, Lamy A; for the CORONARY Investigators. Kidney function after off-pump or on-pump coronary artery bypass graft surgery. A randomized clinical trial. Journal of the American Medical Association , 2014, 311 (21), 2191-2198.


• Cook RJ, Berg K, Lee K-A, Poss JW, Hirdes JP, Stolee P. Rehabilitation in home care is associated with functional improvement and preferred discharge. Archives of Physical Medicine and Rehabilitation , 2013, 94 (6), 1038-1047.


• Garg AX, Devereaux PJ, Yusuf S, Cuerden MS*, Parikh CR, Coca SG, Walsh M, Cook RJ, Whitlock RP, Noiseux N, Novick RJ, Ou Y, Lamy A on behalf of the CORONARY investigators. Coronary artery bypass grafting surgery off- or on-pump revascularisation study: kidney substudy analytic protocol of an international randomised controlled trial. BMJ Open , 2012, 2 (2), 1-8. DOI: 10.1136/bmjopen-2012-001080


• Grewal DS, Sehi M, Cook RJ, Greenfield DS and Advanced Imaging in Glaucoma Study Group. The impact of retardance pattern variability on nerve fiber layer measurements over time using GDx with variable and enhanced corneal compensation. Investigative Opthalmology and Visual Science , 2011, 52 (7), 4516-4524.
• Lemaire M, Islam QS, Shen H*, Khan MA, Parveen M, Abedin F, Haseen F, Hyder Z, Cook RJ, Zlotkin SH. Iron-containing micronutrient powder provided to children with moderate-to-severe malnutrition increases hemoglobin concentrations but not the risk of infectious morbidity: a randomized, double-blind, placebo-controlled, noninferiority safety trial. The American Journal of Clinical Nutrition , 2011, 94 (2), 585-593.
• Sehi M, Flanagan JG, Zeng L, Cook RJ, Trope GE. The association between diurnal variation of optic nerve head topography and intraocular pressure and ocular perfusion pressure in untreated primary open-angle glaucoma. Journal of Glaucoma , 2011, 20 (1), 44-50.
• Thabane L, Wells G, Cook RJ, Platt R, Pogue J, Pullenayegum E*, Matthews DE, McCready T, Devereaux PJ, Cairns J, Yusuf S, the CANadian Network and Centre for Trials Internationally (CANNeCTIN) Investigators. Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: The CANNeCTIN Biostatistics and Methodological Innovation Working Group. Trials , 2011, 12, 48-54.


• Cairns JA, Yusuf S, Cook RJ, Cox J, Dagenais GR, Devereaux PJ, McAlister FA, McCready T and on behalf of CANNeCTIN. CANadian Network and Centre for Trials INternationally (CANNeCTIN): a national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus. Canadian Journal of Cardiology , 2010, 26 (7), 353-358.
• Giangregorio LM, MacIntyre N, Thabane L, Cranney A, Cook R, Papaioannou A. Exercise for improving outcomes after osteoporotic vertebral fracture (Protocol). The Cochrane Library , 2010, Issue 7, Art. No.: CD008618. DOI: 10.1002/14651858.
• Wong RK, Sagar SM, Chen BJ*, Yi GY, Cook RJ. Phase II randomized trial of acupuncture-like transcutaneous electrical nerve stimulation to prevent radiation-induced Xerostomia in head and neck cancer patients. Journal of the Society for Integrative Oncology , 2010, 8 (2), 35-42.


• Stolee P, Poss J, Cook RJ, Byrne K Hirdes JP. Risk factors for hip fracture in older home care clients. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences , 2009, 64A (3), 403-410.
• Stolee P, Poss J, Cook RJ, Byrne K Hirdes JP. Fall-related hip fractures. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences , 2009, 64A (11), 1199.