The SAS System 1 Cox Model for First Gap Time ---------------------------- The PHREG Procedure Model Information Data Set WORK.RHDNASE1 Dependent Variable gtime Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 645 Number of Observations Used 645 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 645 243 402 62.33 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 3031.815 2961.974 AIC 3031.815 2965.974 SBC 3031.815 2972.960 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 69.8417 2 <.0001 Score 65.9424 2 <.0001 Wald 63.4699 2 <.0001 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio trt 1 -0.38282 0.12971 8.7106 0.0032 0.682 fevc 1 -0.02062 0.00277 55.3716 <.0001 0.980 ^LThe SAS System 2 Test for Proportion Hazards Assumption -------------------------------------- The PHREG Procedure Model Information Data Set WORK.RHDNASE1 Dependent Variable gtime Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 645 Number of Observations Used 645 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 645 243 402 62.33 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 3031.815 2960.530 AIC 3031.815 2968.530 SBC 3031.815 2982.503 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 71.2850 4 <.0001 Score 67.0670 4 <.0001 Wald 64.3840 4 <.0001 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio trt 1 -0.99868 0.65671 2.3126 0.1283 0.368 fevc 1 -0.03055 0.01435 4.5277 0.0334 0.970 trtt 1 0.15197 0.15829 0.9217 0.3370 1.164 fevct 1 0.00243 0.00343 0.5019 0.4787 1.002 Linear Hypotheses Testing Results Wald Label Chi-Square DF Pr > ChiSq proportionality_test_trt 0.9217 1 0.3370 proportionality_test_fevc 0.5019 1 0.4787 proportionality_test_global 1.4148 2 0.4929 ^LThe SAS System 3 Cox Model for Second Gap Time ----------------------------- The PHREG Procedure Model Information Data Set WORK.RHDNASE2 Dependent Variable gtime Censoring Variable status Censoring Value(s) 0 Ties Handling BRESLOW Number of Observations Read 227 Number of Observations Used 227 Summary of the Number of Event and Censored Values Percent Total Event Censored Censored 227 81 146 64.32 Convergence Status Convergence criterion (GCONV=1E-8) satisfied. Model Fit Statistics Without With Criterion Covariates Covariates -2 LOG L 780.717 764.848 AIC 780.717 770.848 SBC 780.717 778.032 Testing Global Null Hypothesis: BETA=0 Test Chi-Square DF Pr > ChiSq Likelihood Ratio 15.8690 3 0.0012 Score 15.3704 3 0.0015 Wald 14.8439 3 0.0020 Analysis of Maximum Likelihood Estimates Parameter Standard Hazard Variable DF Estimate Error Chi-Square Pr > ChiSq Ratio trt 1 0.35807 0.22456 2.5426 0.1108 1.431 fevc 1 0.0009323 0.00538 0.0301 0.8623 1.001 gtime1c 1 -0.01431 0.00394 13.2033 0.0003 0.986