D.2 Outcomes in Blood and Marrow Transplantation (EBMT) ======================================================== Description of Variables: id patient ID from state from which a transition occurs to state to which a transition occurs state 1: alive, no recovery or adverse event (transplanted) state 2: alive in remission, recovered from treatment state 3: alive in remission, adverse event occurred state 4: alive, both recovered from treatment and adverse event occurred state 5: alive in relapse (due to treatment failure) state 6: dead (due to treatment failure) trans numbered all possible transitions Tstart start time of a transition (days) Tstop stop time of a transition (days) time gap time between Tstart and Tstop (days) status 1 if a transition is made; 0 otherwise sex.match donor-recipient gender match: no gender mismatch, gender mismatch proph prophylaxis: no, yes year year of transplantation: 1985-1989, 1990-1994, 1995-1998 agecl patient's age (years) at transplant: <=20, 20-40, >40 References: Fiocco M, Putter H and van Houwelingen H (2008). Reduced-rank proportional hazards regression and simulation-based prediction for multi-state models. Statistics in Medicine, 27(21): 4340-4358. de Wreede L, Fiocco M and Putter H (2011). mstate: An R package for the analysis of competing risks and multi-state models. Journal of Statistical Software, 38(7): 1-30. van Houwelingen H and Putter H (2012). Dynamic Prediction in Clinical Survival Analysis. CRC Press, Boca Raton, FL. > ebmt <- read.table("ebmt.dat", header=T) > length(unique(ebmt$id)) [1] 2279 > dim(ebmt) [1] 15512 12 > ebmt[ebmt$id %in% c(1,2),] id from to trans Tstart Tstop time status match proph year agecl 1 1 1 2 1 0 22 22 1 no gender mismatch no 1995-1998 20-40 2 1 1 3 2 0 22 22 0 no gender mismatch no 1995-1998 20-40 3 1 1 5 3 0 22 22 0 no gender mismatch no 1995-1998 20-40 4 1 1 6 4 0 22 22 0 no gender mismatch no 1995-1998 20-40 5 1 2 4 5 22 995 973 0 no gender mismatch no 1995-1998 20-40 6 1 2 5 6 22 995 973 0 no gender mismatch no 1995-1998 20-40 7 1 2 6 7 22 995 973 0 no gender mismatch no 1995-1998 20-40 8 2 1 2 1 0 12 12 0 no gender mismatch no 1995-1998 20-40 9 2 1 3 2 0 12 12 1 no gender mismatch no 1995-1998 20-40 10 2 1 5 3 0 12 12 0 no gender mismatch no 1995-1998 20-40 11 2 1 6 4 0 12 12 0 no gender mismatch no 1995-1998 20-40 12 2 3 4 8 12 29 17 1 no gender mismatch no 1995-1998 20-40 13 2 3 5 9 12 29 17 0 no gender mismatch no 1995-1998 20-40 14 2 3 6 10 12 29 17 0 no gender mismatch no 1995-1998 20-40 15 2 4 5 11 29 422 393 1 no gender mismatch no 1995-1998 20-40 16 2 4 6 12 29 422 393 0 no gender mismatch no 1995-1998 20-40