B. IngallsBrian Ingalls
Associate Professor

Department of Applied Mathematics
University of Waterloo

Office:  MC5187
Phone: 519-888-4567 ext. 35457
Fax:     519-746-4319

Mailing Address
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
e-mail: bingalls@math.uwaterloo.ca

Textbook                           MMSB

Mathematical Modelling in Molecular Systems Biology: an introduction

Supplementary files


AMATH 882 Mathematical Cell Biology

AMATH/BIOL 382 Computational Modelling of Cellular Systems

Synthetic Biology and iGEM

Slides: introduction to Mathematical modeling in synthetic biology (prepared for the aGEM Modelling workshop, Lethbridge Alberta, July 22, 2012)

Waterloo iGEM

Research Interests: Applications of Systems and Control Theory to Molecular Systems Biology and to Synthetic Biology

Computational systems biology involves the development and analysis of computer simulations of intracellular biological processes. These simulations are commonly based on mathematical models composed of ordinary differential equations.

Intracellular biological systems owe their existence to the fact that they have been selected (through evolution) based on their performance. Consequently, in studying these systems, we can apply a reverse-engineering approach; performance measures can be used to assess the efficiency and robustness of their function. Such investigation have lead to the identification of biological ‘design principles’ that help us better understand system behaviour. Mathematical techniques from systems and control theory are directly applicable to this reverse-engineering approach.

A complementary activity is the forward-engineering of intracellular networks, known as synthetic biology. This research area addresses design and implementation of novel biochemical and genetic networks, with far-reaching applications to health, manufacturing, agriculture, and other aspects of biotechnology.