To plot an optimal tour on a Google map, try Plan a Trip.
For an optimal tour to touch down in every airport in North Carolina, including an animation of the flight, see Ron Schreck's NC Flight.
Lincoln regularly traveled a tour through Illinois while he worked as a circuit lawyer. His route can be found at Lincoln's Circuit.
Gas is getting more and more expensive. If you absolutely must make a trip around the largest cities in the United States, try 100 US Cities.
If you need to relocate to the Atlanta area, you might want to visit the elementary schools in Fulton County. An optimal tour can be found at 47 Schools.